红景天提取物的护肤功效及安全性评价研究

doi:10.3969/j.issn.2097-2806.2023.10.009

Abstract

Abstract:

This paper aimed to study the skincare efficacy and safety of Rhodiola rosea extract. The antioxidant effect of Rhodiola rosea extract was verified through DPPH free radical scavenging experiment. The results show that within a certain concentration range, Rhodiola rosea extract can effectively eliminate DPPH free radicals and reactive oxygen species, which plays a protective role on the cells damaged by oxidation, and has a certain antioxidant effect. The effect of Rhodiola rosea extract on maintaining skin elasticity was verified through the inhibition rate of elastase, and Rhodiola rosea extract can effectively inhibit elastase activity. The inhibitory effect of Rhodiola rosea extract on melanogenesis was verified through the inhibition rate of tyrosinase activity and the elimination rate of melanin in mouse melanoma cells. Rhodiola rosea extract can significantly inhibit tyrosinase activity, delay melanogenesis, and has potential whitening effects. The safety of Rhodiola rosea extract was verified through a repeated open application test on human skin. The results show that no adverse skin reactions occurred after 48 hours, indicating that within a certain concentration range, Rhodiola rosea extract has no irritating effect on human skin.

Key words: Rhodiola rosea, skin care, antioxidant, safety

CLC Number:

TQ658

Zhou Yan, Han Ruina. Study on the skincare efficacy and safety evaluation of Rhodiola rosea extract[J].China Surfactant Detergent & Cosmetics, 2023, 53(10): 1180-1185.

Figures/Tables 8

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References 10

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反应程度	评分等级	皮肤反应临床表现
-	0	阴性反应
±	1	微弱红斑、皮肤干燥、皱褶
+	2	红斑、水肿、丘疹、风团、脱屑、裂隙
++	3	明显红斑、水肿、水疱
+++	4	重度红斑、水肿、大疱、糜烂、色素沉着或色素减退、痤疮样改变

样品名称	评分等级	反应人数/例
样品名称	评分等级	30 min后	24 h后	48 h后
红景天提取物	0	28	29	30
	1	1	—	—
	2	1	1	—
	3	—	—	—
	4	—	—	—

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Study on the skincare efficacy and safety evaluation of Rhodiola rosea extract

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