Abstract:

The hand sanitizers containing dodecyl dipropylene triamine （DDT, antibacterial component） were prepared with the thickening systems such as AES-6501-NaCl, CAB-35-AES-NaCl, acrylic acid-2-acrylamide-2-methylpropanesulfonic acid, 6502-NaCl （Na₂SO₄）, and polyethylene glycol 6000 distearate （638）. The same mass fraction of DDT was added to these systems respectively. Then the viscosity and transmittance were investigated to judge the compatibility of these thickening systems with DDT. Single factor experiments were further carried out and the formula was optimized. The hand sanitizer containing DDT was thus prepared. Then the properties of the hand sanitizer were tested, including stability, viscosity, active substance content, pH value, foam height and bactericidal performance. The experimental results show that, the 638 system is compatible with DDT, while other thickening systems are not compatible with DDT. After high-temperature and low-temperature stability tests, the antibacterial hand sanitizer containing DDT shows no phase separation, no precipitation and no obvious color change, indicating that it has good stability. The viscosity is 2 767 Pa·s, which proves that the hand sanitizer can stay on the skin for a long time. The average value of active substance content is 10.2% and the pH value is 5.5, which all meet the national standard. The average bactericidal rates of the hand sanitizer against Escherichia coli and Staphylococcus aureus in 2 minutes were 97.63% and 98.96%, respectively.

Key words: dodecyl dipropylene triamine, hand sanitizer, sterilization, thickening