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China Surfactant Detergent & Cosmetics ›› 2020, Vol. 50 ›› Issue (9): 615-619.doi: 10.3969/j.issn.1001-1803.2020.09.006

• Development and application • Previous Articles     Next Articles

Diversity of skin microbiome in children aged 0-2 years old with mild perioral eczema and the effects of emollients treatment on the microflora

ZHENG Yu-mei1(),WANG Qian1,MA Lai-ji2,CHEN Yuan-yuan2,GAO Ying3,SONG Li-ya1()   

  1. 1. Key Laboratory of Plant Resources Research and Development, College of Science, Beijing Technology and Business University, Beijing 100048, China
    2. Shanghai Jahwa Corporation, Shanghai 200082, China
    3. Capital Institute of Pediatrics, Beijing 100000, China
  • Received:2019-12-17 Revised:2020-08-30 Online:2020-09-22 Published:2020-09-23
  • Contact: Li-ya SONG E-mail:18810439969@163.com;songly@th.btbu.edu.cn

Abstract:

16SrRNA gene high-throughput sequencing technique was used to study the difference of bacterial composition between mild eczema skin and healthy skin of 0-2 year-old children as well as before and after using emollient. It was found that compared with the healthy group, the abundance of Actinomycetes, Azospirillum and Rhodococcus increase significantly in eczema group, while the abundance of [Prevotella], Limnobacter, Agrobacterium and Lactobacillus decrease significantly (P<0.05). At the species level, the abundance of Staphylococcus aureus P<0.01), Hyphomicrobium zavarzinii, and Streptococcus anginosus P<0.05) are significantly higher, while the abundance of Staphylococcus haemolyticusP<0.05) and Pseudoxanthomonas mexicanaP<0.001) are significantly lower. After the use of emollients for one week, the clinical symptoms of eczema are improved, and the number of bacteria operational taxonomic units (OTUs) shared by the healthy and post-treatment mild eczema groups increase compared with those shared by the healthy and mild eczema groups. Taxonomic composition analysis reveals that Anoxybacillus Anoxybacillus kestanbolensis), Micrococcus Micrococcus luteus), and Mycoplana levels increase significantly after applying emollients, while Actinomyces, Azospirillum, Hyphomicrobium H.zavarzinii), and Burkholderia Burkholderia bryophila) decrease significantly (P<0.05). The results show that the bacterial composition of mild perioral eczema-like skin is different from that of healthy skin, which is related to the significant increase of Staphylococcus aureus. Moisturizing cosmetics such as emollients can relieve mild eczema and it is related to the decrease of the abundance of pathogenic bacteria such as Actinomycetes and Staphylococcus aureus.

Key words: eczema, perioral skin, skin bacteria, emollients

CLC Number: 

  • TQ658