川芎提取物美白双靶点活性研究

doi:10.3969/j.issn.1001-1803.2020.04.007

Abstract

Abstract:

The activities of Ligusticum Chuangxiong Hort. （LH） extracted from different solvents and polar sections were investigated with DPPH free radical scavenging rate and mushroom tyrosinase inhibition rate as evaluation indicators. The effects of LH extracts on melanin contents and intracellular tyrosinase activity under various stimuli （α-MSH、Forskolin、IBMX）were detected in cells. The scavenging ability of LH extracts to intracellular ROS induced by UV was estimated by DCFH-DA. The results display that the 50% ethanol-water extracts of LH possess great antioxidant and mushroom tyrosinase inhibitory effects. The LH extracts can achieve good inhibitory effect on melanin contents and intracellular tyrosinase activity stimulated by three stimuli. The LH extracts eliminate ROS induced by UV in a dose-dependent manner. LH extracts has whitening efficacy by dual targets of inhibiting intracellular tyrosinase and scavenging ROS.

Key words: Ligusticum chuanxiong Hort., whitening, dual-target, melanin, antioxidant, tyrosinase

CLC Number:

TQ658

WANG Yong-heng,LIANG Yan-hui,SUN Pei-dong. Study on the dual-target whitening activities of Ligusticum chuanxiong Hort. extracts[J].China Surfactant Detergent & Cosmetics, 2020, 50(4): 249-254.

Figures/Tables 6

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References 14

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Study on the dual-target whitening activities of Ligusticum chuanxiong Hort. extracts

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