三七提取物的抗衰老功效性研究

doi:10.3969/j.issn.1001-1803.2020.11.008

Abstract

Abstract:

An aging animal model was established and the anti-aging effects of Sanqi extract as a cosmetic ingredient were evaluated. D-galactose was injected subcutaneously for 45 days to obtain an aging mouse model. The samples were continuously applied to the hairless area for 50 days. Multifunctional skin analyzer was used to measure the skin color, pigment, and pores of the mouse skin. Collagen I （Col-I）, Collagen III （Col-III） and vimentin （VIM） were evaluated by immunohistochemical staining. Total superoxide dismutase （T-SOD）, catalase （CAT）, glutathione peroxidase （GSH-Px） and malondialdehyde （MDA） in skin tissue homogenates were measured to evaluate the changes in antioxidant capacity after sample treatment. The results showed that the ointment containing 4% Sanqi extract could significantly increase the content of Col-I, Col-III and VIM by immunohistochemical staining. Sanqi ointment had a good dosage-dependent effect on the up-regulation of T-SOD and GSH-Px. Compared with the blank matrix group, the T-SOD activity was increased by 36.62%, the CAT activity was increased by 20.39%, and the GSH-Px activity was increased by 68.77% after treatment with the ointment containing 4% Sanqi extract.

Key words: cosmetic raw material, Sanqi, animal model, anti-aging, histological staining

CLC Number:

TQ658

GAO Si-yu,HUO Tong,LI Xue-tao,YAO Xue-min,LU Jun-cong,QUAN Qiang-hua. Study on the anti-aging efficacy of Sanqi extract[J].China Surfactant Detergent & Cosmetics, 2020, 50(11): 783-787.

Figures/Tables 6

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Study on the anti-aging efficacy of Sanqi extract

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