蚌肉多糖提取物抗UVB致人真皮成纤维细胞损伤的研究

doi:10.3969/j.issn.1001-1803.2019.10.005

Abstract

Abstract:

Human dermal fibroblasts（HDF-a）and UVB（306 nm）were used to construct a skin photoaging model. The anti-photoaging ability of polysacchride extract from Hyriopsis cumingii（HCP）was investigated by using this model, and its effects on inhibiting oxidative damage and inflammation injury were evaluated respectively. Results show that HCP with mass concentration of 0.1,1 and 10 g/L can significantly improve the survival rate of photoaging and damage HDF-a , up to 86.63%. In terms of inhibiting oxidative damage, the extract can effectively increase intracellular SOD activity and GSH content and reduce MDA content, and enhance the ability of cells to scavenge free radicals. In terms of alleviating inflammation, the extract can block the NF-κB signaling pathway and inhibit the release of inflammatory factors such as IL-6.

Key words: cosmetic additive, polysaccharide extract, Hyriopsis cumingii, photoaging, UVB

CLC Number:

TQ658

CHEN Xin-xin,LUO An-ling,LI Jia-luo,ZHENG You-li,CONG Feng-song. Study on the anti- UVB-induced photoaging and damage of human dermal fibroblasts by polysacchride extract from Hyriopsis cumingii[J].China Surfactant Detergent & Cosmetics, 2019, 49(10): 656-660.

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References 17

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	对照组	UVB模型组	UVB+ρ（HCP）/（g·L^-1）
	对照组	UVB模型组	0.1	1	10
HDF-a存活率/%	100.00±5.87^*	45.32±3.84^#	60.06±4.75^#*	71.15±4.15^#*	86.63±4.70^#*

Study on the anti- UVB-induced photoaging and damage of human dermal fibroblasts by polysacchride extract from Hyriopsis cumingii

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