Abstract:

The giant salamander peptides have the functions of anti-oxidation, anti-aging, whitening and moisturizing, and promoting wound healing, which have great application prospects in cosmetics. In this study, B16 mouse melanoma cells were used to study the effect of giant salamander peptides on tyrosinase activity and melanin content. Human keratinocyte （HaCaT） cells were used to study the effect of giant salamander peptides on cell repair ability. The liquid crystal emulsification system was used as the carrier, and the giant salamander peptides as the active ingredient to prepare the giant salamander peptides compound liquid crystal emulsion. The skin repair ability was evaluated by the skin mechanical barrier disturbance model in mice. Its effect on the water content of the skin stratum corneum and transepidermal water loss was also analyzed. The results show that giant salamander peptides are able to inhibit tyrosinase activity and reduce melanin production, and can promote cell repair to a certain extent. Moreover, the giant salamander peptides compound liquid crystal emulsion can promote the repair of the mouse skin barrier, and promote the regeneration and healing of the epidermis. It also has a good whitening, water-locking and moisturising effect. Overall, the giant salamander peptides have excellent whitening, moisturizing, and skin-repairing abilities, and have good application prospects in cosmetics.

Key words: giant salamander peptides, liquid crystal emulsion, whitening, skin repair