用于抗糖化功效评价的细胞模型研究现状及应用前景

doi:10.3969/j.issn.2097-2806.2023.12.013

Abstract

Abstract:

This paper reviews the mechanism of glycation reaction, the classification of advanced glycation end products （AGEs）, the effects of glycation on skin, the evaluation methods of anti-glycation efficacy and the current research status of the cell models used for the evaluation of anti-glycation efficacy at home and abroad. According to the different cell functions, the application of five types of keratinocytes （HaCaT）, fibroblasts, immune cells （RAW264.7/THP-1）, melanocytes and vascular endothelial cells （HUVECs） in the evaluation cell model of anti-glycation efficacy was summarized. They are aimed at the skin barrier damage, collagen loss, pigmentation, oxidative stress and inflammation caused by glycation. According to the different modeling stimulation modes, the application of three stimulation modes of high glucose, methylglyoxal/glyoxal （MGO/GO） and AGEs in the cell model of glycation injury was summarized, aiming at the early stage, middle and late stage of the mechanism of glycation reaction and the action stage of AGEs. This review looks forward to the application prospect of cell models for anti-glycation efficacy evaluation, in order to provide an experimental basis for the establishment of standard methods for anti-glycation efficacy evaluation cell models and provide a theoretical basis for the screening of anti-glycation efficacy raw materials.

Key words: anti-glycation, cell model, cosmetic efficacy evaluation, advanced glycation end products （AGEs）

CLC Number:

TQ658

Chencan Cao, Qidan Tan, Lei Liu, Xiaoyu Yang, Haifeng Chen. Cell model research status and application prospects for the evaluation of anti-glycation efficacy[J].China Surfactant Detergent & Cosmetics, 2023, 53(12): 1451-1458.

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References 58

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Cell model research status and application prospects for the evaluation of anti-glycation efficacy

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