高效液相色谱测定化妆品原料羟丙基四氢吡喃三醇的含量及构型比例

doi:10.3969/j.issn.2097-2806.2023.06.015

Abstract

Abstract:

A method for determination of the content and isomer distribution of a cosmetic raw material, i.e., hydroxypropyl tetrahydropyrantriol, was established by high performance liquid chromatography. Samples were extracted with water and then were separated by CAPCELL PAK ADME column and determined by differential refractive index detector. The column temperature was 35 ℃, the detector temperature was 40 ℃, and the flow rate was 1.0 mL/min. The results showed that, it had good linearity within the range of 0.1-2.0 mg/mL for hydroxypropyl tetrahydropyrantriol, with the correlation coefficient above 0.999 9. The recoveries were 99.3%-99.6%, with the relative standard deviations （n=3） lower than 0.76%. The limit of detection and the limit of quantitation were 0.03% and 0.10%, respectively. This method is simple, accurate and reproducible, which is suitable for both determination of the content and the isomer distribution of hydroxypropyl tetrahydropyrantriol.

Key words: hydroxypropyl tetrahydropyrantriol, high performance liquid chromatography, determination, isomer distribution

CLC Number:

TQ658

Yu Haiying, Qiao Zhenyun, Li Qiyan, Hu Defu, Niu Shuijiao, Wang Faping. Determination and isomer distribution of a cosmetic raw material hydroxypropyl tetrahydropyrantriol by HPLC[J].China Surfactant Detergent & Cosmetics, 2023, 53(6): 721-724.

Figures/Tables 4

Fig. 1

Fig. 2

Tab. 1

Tab. 2

References 11

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序号	本底值/mg	加标量/mg	测得量/mg	回收率/%	平均回收率/%	RSD/%
1	53.5	40	93.4	99.73	99.4	0.76
2	54.4		93.8	98.56
3	53.4		93.4	99.98
4	55.2	50	104.6	98.85	99.3	0.40
5	53.7		103.5	99.59
6	54.2		103.9	99.45
7	56.0	60	116.1	100.09	99.6	0.45
8	52.9		112.4	99.21
9	54.1		113.8	99.54

编号	测得含量/%	标示含量/%	构型比例/%
编号	测得含量/%	标示含量/%	（β,S）构型	（β,R）构型
原料1	33.2	30	38	62
原料2	31.0	30	92	8
原料3	9.8	30	42	58
原料4	10.6	30	32	68
原料5	19.8	30	51	49
原料6	32.7	30	48	52
原料7	16.2	30	55	45
原料8	84.5	>90	91	9
原料9	97.9	>90	100	/
原料10	97.4	>90	100	/

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Determination and isomer distribution of a cosmetic raw material hydroxypropyl tetrahydropyrantriol by HPLC

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