神经酰胺复合物对光损伤3D全层皮肤模型的作用研究

doi:10.3969/j.issn.1001-1803.2023.01.007

Abstract

Abstract:

In this study, a 3D full-thickness skin model with UV-induced damage was reconstructed to evaluated the effects of ceramide complex. Paraffin section immunohistochemistry and immunofluorescence staining were used to observe the morphology of sample cells and tissues, detect the content changes of ECM protein such type I collagen, a number of late differentiation markers: filaggrin, claudin-1, LCE-1A as well as stress-related enzymes in the model. The results show that ceramide complex can significantly alleviate epidermal differentiation disorder, collagen loss, barrier damage and skin stress defense response caused by UV irradiation. Therefore, the complex reduces a series of negative effects caused by ultraviolet radiation on skin, which has a preventive and repair effect on skin from UV damage.

Key words: ceramide complex, UV-induced damage, 3D full-thickness skin model, preventive maintenance

CLC Number:

TQ658

Cai Zhuo, Lu Yuan, Wang Bingjie, Liu Qiaoyuan. Efficacy evaluation of ceramide complex on 3D full-thickness skin model under UV-induction[J].China Surfactant Detergent & Cosmetics, 2023, 53(1): 47-53.

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Efficacy evaluation of ceramide complex on 3D full-thickness skin model under UV-induction

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