神经酰胺纳米乳液的制备及透皮性能研究

doi:10.3969/j.issn.1001-1803.2021.10.004

Abstract

Abstract:

Ceramide is an important lipid in the stratum corneum of skin and plays an indispensable role in maintaining the normal physiological functions of skin. The skin contains the most abundant types of ceramides and there are currently 15 types of ceramides that have been detected. And among them, ceramide3 （Cer3） has the highest content in the skin and is an essential ingredient for regulating skin barrier function. However, Cer3 is very easy to crystallize when directly applied and thus it needs a carrier to improve its stability during application. Therefore, to improve the stability and bioavailability of Cer3, Cer3 nanoemulsions were prepared by high-pressure homogenization method. The effects of the amount of lecithin, the mass ratio of glycerol to water, the homogenization pressure, the number of cycles and the amount of phytosphingosine on the particle size and stability of the emulsions were studied. It is found that when the mass fraction of lecithin is 4%, the mass ratio of glycerol to water is 7:1, the average pressure is 90 MPa and the number of cycles is 9, the emulsion has good stability. Furthermore, phytosphingosine was added to the system to improve the storage stability of Cer3 nanoemulsion at high temperature. The results show that when the mass fraction of phytosphingosine is 1.5%, the Ostwald ripening rate of Cer3 nanoemulsion is decreased from 6.06 to 1.53 and the Cer3 nanoemulsion is gel-like at this time. It is found that the nanoemulsion particles are spherical and have a particle size of approximately 200 nm as observed by TEM. The results of Zeta potential show that the Cer3 nanoemulsion carries a positive charge and the potential is 36.67 mV. The transdermal performance of the Cer3 nanoemulsions with different mass fractions of phytosphingosine was also studied. It is found that the transdermal content of Cer3 is closely related to the potential value of the Cer3 nanoemulsion. When the mass fraction of phytosphingosine is 1.5%, the transdermal content of Cer3 is increased from 3.02 μg/cm ² to 7.12 μg/cm ², indicating that the addition of phytosphingosine can effectively improve the transdermal performance of Cer3.

Key words: ceramide, storage stability, phytosphingosine, Ostwald ripening, transdermal performance

CLC Number:

TQ658

Wang Yuxuan,Liang Rong,Luo Yeyuan. Study on the preparation and transdermal performance of the ceramide nanoemulsion[J].China Surfactant Detergent & Cosmetics, 2021, 51(10): 949-955.

Figures/Tables 7

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References 22

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Study on the preparation and transdermal performance of the ceramide nanoemulsion

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