Abstract:

With the outbreak of a series of epidemics, disinfection and sterilization have gradually become the norm. Because a single product may be limited in disinfection and sterilization capacity and easy to generate drug resistance, the research and development of new compound products are particularly important. Herein, a mixed system based on a novel quaternary ammonium salt with organic counterion, didecyl dimethyl ammonium formate （DDAF） , and an easily biodegradable gemini quaternary ammonium salt, 1,4-bis （lauroyl propyl dimethyl ammonium chloride） butene （GC-B） , and the commonly used quaternary ammonium salts on the market, dodecyl dimethyl benzyl ammonium chloride （1227） and didecyl dimethyl ammonium chloride （2280） , was prepared and tested for their antibacterial properties. The optimal formula ratio was obtained through the design and optimization of uniform experiments. The best proportion of mix-disinfectant is:3% DDAF, 6% GC-B, 0.5% 1227 and 0.5% 2280. The antibacterial performance of this formula was compared with that of two commercially available products. The antibacterial rates of this product against Staphylococcus aureus, Escherichia coli and Candida albicans are all 100%, which is better than the two commercially available products. In terms of cost, the cost of this formula is basically the same as the cost of the commercially available products. The DDAF and GC-B in this formula are green and environmentally friendly quaternary ammonium salts, and the bacteria show no drug resistance. This formula has the potential of further promotion and utilization.

Key words: quaternary ammonium salt with organic counterion, Gemini quaternary ammonium salt, formulation, bacteriostatic property