汤原温泉水联合甘草酸二钾抗炎舒敏功效的研究

doi:10.3969/j.issn.1001-1803.2021.05.010

Abstract

Abstract:

Keratinocytes and 3D skin models were applied to establish anti-inflammatory and anti-allergy models. Based on this model, the effects of hotspring water （HW） combined with dipotassium glycyrrhizinate （DG） were studied. The results showed that, the safe concentration of DG was below 100 μmol/L combined with 1% HW. The combination group could decrease the activity of NF-κB by 56% （NF-κB was induced by inflammatory cocktail）, and could significantly reduce the secretion of IL-1α and IL-6. The combination group also provided anti-allergy effect by reducing the secretion of VEGF and the expression levels of allergy related genes including TRPV1 and COX-2.

Key words: reconstructed human epidermis model, Yubara hotspring water, dipotassium glycyrrhizinate, anti-inflammatory, anti-allergy

CLC Number:

TQ658

QIAO Wu,JIA Ting-han,LU Jing,HE Lai-jian. Study of anti-inflammatory and anti-allergy effects of Yubara hotspring water combined with dipotassium glycyrrhizinate[J].China Surfactant Detergent & Cosmetics, 2021, 51(5): 433-437.

Figures/Tables 6

Tab. 1

Tab. 2

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References 20

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成分	ρ/（mg·L^-1）
硅（Si）	17.1
钠（Na）	54.2
钾（K）	1
钙（Ca）	<0.5
铝（Al）	<0.1
铬（Cr）	<0.1
铜（Cu）	<0.1
铁（Fe）	<0.1
锰（Mn）	<0.1
镁（Mg）	<0.1

基因	正向引物	反向引物
TRPV1	CTGCCCGACCATCACAGTC	CTGCGATCATAGAGCCTGAGG
COX-2	TAAGTGCGATTGTACCCGGAC	TTTGTAGCCATAGTCAGCATTGT
GAPDH	GGAGCGAGATCCCTCCAAAAT	GGCTGTTGTCATACTTCTCATGG

Study of anti-inflammatory and anti-allergy effects of Yubara hotspring water combined with dipotassium glycyrrhizinate

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