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China Surfactant Detergent & Cosmetics ›› 2018, Vol. 48 ›› Issue (8): 466-471.doi: 10.13218/j.cnki.csdc.2018.08.009

• Analytical methods and testing • Previous Articles     Next Articles

Evaluation of uncertainty in the determination of benzalkonium chloride in cosmetics by HPLC

WANG Tao1,LI Zhuo1,JIA Han-bing1,SUN Xiao1,TIAN Ren-fang2,XUN Ying3   

  1. 1.Xi'an Institute for Food and Drug Control,Xi'an,Shaanxi 710054,China;
    2.Xi'an Yikang Pharmaceutical Chains Co.,Ltd., Xi'an,Shaanxi 710054,China;
    3.Weinan Hospital of Traditional Chinese Medicine,Weinan,Shaanxi 714000,China
  • Online:2018-08-22 Published:2019-03-22

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Abstract: Uncertainties from the determination procedure of three substances of benzalkonium chloride (dodecyldimethylbenzylammonium chloride (C12),tetradecyldimethylbenzylammonium chloride (C14) and hexadecyldimethylbenzylammonium chloride (C16) in Safety and Technical Standards for Cosmetics (2015 Edition) by high performance liquid chromatography (HPLC) were assessed.The mathematical model was established,and the source of uncertainty was investigated and quantified.The combined standard uncertainty and expanded uncertainty were calculated.The results show that the expanded uncertainties are 0.027%,0.029% and 0.006% (95% confidence level,k=2) when the mass fraction of benzalkonium chloride (C12,C14 and C16 ) in cosmetics are 0.045%,0.048% and 0.010%,respectively.The main sources of the uncertainty are analyzed,and improved method is introduced.

Key words: cosmetics, benzalkonium chloride, high performance liquid chromatography (HPLC), uncertainty

CLC Number: 

  • TQ658