棕榈酰三肽-5皮肤美白功效及机制研究

doi:10.13218/j.cnki.csdc.2018.03.009

Abstract

Abstract: To evaluate skin whitening efficacy and mechanism of palmitoyl tripeptide-5,the cell viability was detected by MTT method,B16 guinea pig melanoma cell models treated by α-melanocyte stimulating hormone (α-MSH) and hyperpigment of UVB-stimulated dorsal skin of guinea pigs were measured.Activity of tyrosinase,the mRNA expression of MITF and tyrosinase were investigated.Results show that palmitoyl tripeptide-5 exert a skin whitening efficacy by inhibiting melanin production via downregulation of MITF and tyrosinase expression,inhibiting activity of tyrosinase in melanocytes.Colorimetric analysis shows that the palmitoyl tripeptide-5 significantly inhibit the pigmentation and reduce the gray value in UVB-irradiated guinea pig dorsal skin area (P<0.05).

Key words: whitening, palmitoyl tripeptide-5, UVB, B16 cell, guinea pig

CLC Number:

TQ658

GAO Ya-qian, TANG Jian, WANG Zhi-yong, WEI Xiao-li, CAI Ya. Skin whitening efficacy and mechanism study of palmitoyl tripeptide-5[J].China Surfactant Detergent & Cosmetics, 2018, 48(3): 166-171.

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Skin whitening efficacy and mechanism study of palmitoyl tripeptide-5

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