气相色谱-质谱联用法测定膏霜类化妆品中10种合成麝香

doi:10.13218/j.cnki.csdc.2017.05.011

Abstract

Abstract: An analytical method was established for simultaneous determination of ten kinds of synthetic musk in cream cosmetics using gas chromatography-mass spectrometry (GC-MS).Samples were spiked with deuterium-labeled isotope internal standards and extracted by n-hexane.Then the extract was purified with matrix solid-phase dispersion (MSPD) and separated by a VF-WAXms capillary column.All the compounds were detected with selected ion monitoring (SIM) scanning mode.Quantification was carried out using standard plot calibration.Results show that the ten kinds of synthetic musk display a good linear relationship within the mass concentration range of 0.01-0.2 mg/L and the correlation coefficients are all higher than 0.99.The quantification limits (LOQs) of the synthetic musk are in the range of 0.05-0.10 mg/kg.Values of spiked recoveries are found to be from 80.1% to 102.2% with all relative standard deviations (RSD) lower than 5%.

Key words: cosmetics, synthetic musk, gas chromatography-mass spectrometry

CLC Number:

TQ658

NING Xiao-jun, ZHOU Jing, FU Chang-yu. Determination of ten kinds of synthetic musk in cream cosmetics by GC-MS[J].China Surfactant Detergent & Cosmetics, 2017, 47(5): 292-296.

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Determination of ten kinds of synthetic musk in cream cosmetics by GC-MS

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