H4GeW12O40/Cu3(BTC)2催化Biginelli反应合成3,4-二氢嘧啶-2(1H)-酮衍生物

doi:10.13218/j.cnki.csdc.2016.06.009

Abstract

Abstract: Six kinds of 3,4-dihydropyrimidine-2(1H)-one derivative were prepared via Biginelli-type condensation by one-pot method with ethyl acetoacetate,aromatic aldehyde and urea as starting materials,anhydrous ethanol as solvent and H₄GeW₁₂O₄₀/Cu₃(BTC)₂ as catalyst.The catalyst was prepared by loading of germanic-tungstic acid on metal organic skeleton by impregnation method.Structures of the target compounds were characterized by melting point determination,¹H NMR,IR,and MS.The experimental results showed that,under the conditions of fixed aromatic aldehyde feed of 0.04 mol;n(aromatic aldehyde)∶n(ethyl acetoacetate)∶n(urea)=1∶1.5∶1.5;the dosage of catalyst at 4.0% of total mass of the starting materials;reaction temperature at 90 ℃;and reaction time of 90 min;the yield of the target products achieves 63.0%-76.3%.

Key words: Biginelli reaction, H₄GeW₁₂O₄₀/Cu₃(BTC)₂, catalytic, 3,4-dihydropyrimidine-2(1H)-one derivative

CLC Number:

TQ460

GONG Wen-peng,MA Hai-qin,ZHOU Zhou,YANG Shui-jin. Synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives via Biginelli reaction with H₄GeW₁₂O₄₀/Cu₃(BTC)₂ as catalyst[J].China Surfactant Detergent & Cosmetics, 2016, 46(6): 344-348.

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Synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives via Biginelli reaction with H₄GeW₁₂O₄₀/Cu₃(BTC)₂ as catalyst

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Synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives via Biginelli reaction with H4GeW12O40/Cu3(BTC)2 as catalyst

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Synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives via Biginelli reaction with H₄GeW₁₂O₄₀/Cu₃(BTC)₂ as catalyst