Abstract: By selecting and optimizing the formulation of components,a quaternary ammonium salt based antibacterial hand sanitizer was prepared.The formulation (expressed as mass fraction) consists of 0.75% sodium ethoxylated dodecyl alcohol sulfate (AES),2.25% tetradecylmethyldihydroxyethylammonium bromide (TMDAB),20% cocamidopropyl betaine (CAB-35),0.25% disodium ethoxylated alcohol succinic acid monoester sulfonate (MES),1.5% coconut acid diethanolamide (6501),1% glycerin,0.1% dimethylol dimethyl hydantoin (DMDMH),a little amount of fragrance and colorant,as well as a small amount of citric acid for adjusting pH value.The balance is distilled water.Test results of the product showed that the sterilization efficacy for Escherichia coli and Staphylococcus aureus achieves 99.99% and 100% respectively.The stability and foaming performance of the product are well.Besides,its production cost is rather low.As comparing with some liquid hand cleaners from the market,the prepared product shows somewhat better antibacterial efficacy.

Key words: hand sanitizer, quaternary ammonium salt, antibacterial, formulations