Welcome to China Surfactant Detergent & Cosmetics, Today is
China Surfactant Detergent & Cosmetics

China Surfactant Detergent & Cosmetics ›› 2015, Vol. 45 ›› Issue (5): 294-297.doi: 10.13218/j.cnki.csdc.2015.05.013

• Analyticalmethodsandtestin • Previous Articles    

Determination of formaldehyde releasing type anticeptics in cream type cosmetic products by high performance liquid chromatography

LI Yan-bo1,2, ZHAO Xiao-dong3, LU Jun3, GUO Chun-mei3, CHEN Xiao-hui1   

  1. 1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China;
    2.Department of Physics and Chemistry,Liaoning Institute for Food Inspection and Testing,Shenyang,Liaoning 110015,China;
    3.Department of Cosmetics,Liaoning Institute for Drug Inspection and Testing,Shenyang,Liaoning 110023,China
  • Online:2015-05-22 Published:2019-04-02

PDF (PC)

413

Like

Abstract: A HPLC method for simultaneous determination of 1,3-dihydroxylmethyl-5,5-dimethylhydantoin (DMDMH),1-hydroxymethyl-5,5-dimethylhydantoin (1-MDMH) and 5,5-dimethylhydantoin (DMH) in cream type cosmetic products was established.The separation is performed on a Waters Atlantis T3 C18 column (250 mm×4.6 mm,5 μm) with the mobile phase consisting of acetonitrile＋0.1% formic acid solution at flow rate of 1.0 mL/min for gradient elution.The detector is diode array type with wavelength of 210 nm.The column temperature is set at 35 ℃.Results showed that the calibration curves display good linearity within the ranges of 17.86-595.20,17.65-588.39 and 18.05-601.67 mg/L with correlation coefficient of 0.999 5,0.999 7 and 0.999 8 for DMDMH,1-MDMH and DMH respectively.The recoveries are within ranges of 82.6%-106.2%,98.4%-110.7% and 98.6%-113.0% respectively.

Key words: cosmetics, high performance liquid chromatography, anticeptics

CLC Number: 

  • TQ658