高锰酸钾用量对制备香紫苏内酯和降龙涎二醇的影响

doi:10.13218/j.cnki.csdc.2015.02.011

Abstract

Abstract: Sclareolide was synthesized via potassium permanganate oxidation with sclareol as starting material.Besides,ambradiol was synthesized via potassium permanganate oxidation with sclareol as starting material and followed by lithium aluminum hydride reduction.Both the two products were characterized by IR,¹HNMR and ¹³CNMR.Effect of KMnO₄ dosage on the preparation of sclareolide and ambradiol was examined.Results showed that,based on 25~30 ℃ of reaction temperature for 5 h,when potassium permanganate dosage is n(sclareol)∶n(KMnO₄)=1∶5.6,yield of sclaeolide achieves 38.0% and that of ambradiol achieves 22.5%.

Key words: sclareolide, ambradiol, potassium permanganate, oxidation

CLC Number:

TQ655

LI Li-hui, LÜ Yan-yu, YANG Shao-xiang, LIU Yong-guo, TIAN Hong-yu. Influence of potassium permanganate dosage on preparation of sclareolide and ambradiol[J].China Surfactant Detergent & Cosmetics, 2015, 45(2): 107-109.

References

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Influence of potassium permanganate dosage on preparation of sclareolide and ambradiol

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