四物汤美白功效评价及其药效关系研究

doi:10.13218/j.cnki.csdc.2015.01.011

Abstract

Abstract: Siwu-tang was prepared by water extraction of four kinds of Chinese traditional herb medicine.DPPH (1,1-diphenyl-2-picryl-hydrazyl) method was adopted to measure the antioxidant activity of the Siwu-tang and ultraviolet spectrophotometry was adopted to measure the tyrosinase inhibitory activity.Then the whitening efficacy of Siwu-tang was comprehensively evaluated.Meanwhile,taking DPPH free radical scavenging ratio and tyrosinase inhibitory ratio as assessment indices,as well as adopting uniform design method,the relationship between dosage ratio of the Siwu-tang and the whitening efficacy was investigated.Results showed that,the Siwu-tang displays rather high DPPH free radical scavenging capacity.With respect to activity of tyrosinase,it displays inhibitory action at high mass concentration,while at lower mass concentration it displays activation effect.In the uniform designed experiment,the results showed that when the mass ratio in the composition of the Siwu-tang Radix Angelica sinensis,Rhizoma Chuanxiong,Radix Paeoniae Alba and Radix Rehmanniae Praeparata is 85∶66∶10∶199,the inhibitory ratio of tyrosinase activity achieves 24.3%,and the scavenging ratio of DPPH free radicals achieves 95.2%.

Key words: whitening, Siwu-tang, 1,1-diphenyl-2-picryl-hydrazyl, tyrosinase, uniform design

CLC Number:

TQ658.5

YOU Zhuo-ying, HE Qiu-xing, LI Xin-en, HUANG Yong-hong, LIN Chun-yu. Study on the whitening efficacy of Siwu-tang and the relationshipwith its pharmacodynamic function[J].China Surfactant Detergent & Cosmetics, 2015, 45(1): 45-48.

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Study on the whitening efficacy of Siwu-tang and the relationshipwith its pharmacodynamic function

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