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日用化学工业:2017,Vol.>>Issue(12):698-702
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“太空人参酵母”对在模拟微重力下人原代成纤维细胞的保护作用
宋肖洁,史晓婷,吴越
(伽蓝(集团)股份有限公司研发中心,上海 200233)
Protective effect of “space ginseng yeast” on human primary fibroblasts under microgravity condition
SONG Xiao-jie,SHI Xiao-ting,WU Yue
(R&D Center, JALA Corporation, Shanghai 200233, China)
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投稿时间:2017-08-18    
中文摘要: 通过多指标、多种实验手段考察“太空人参酵母”对人原代成纤维细胞的保护作用。结果表明,“太空人参酵母”能改善因微重力导致的细胞形态改变及存活率降低;能恢复细胞骨架蛋白Tubulin,胞外基质蛋白Integrin和Fibronectin的表达及有效排列;能抑制MMP-1蛋白表达异常。稀释20~500倍的“太空人参酵母”的保护作用较好,以稀释100倍的“太空人参酵母”的保护作用最为明显。
Abstract:Through the multi-index parameters, a variety of experiments have been designed to verify the protection effects of “space ginseng yeast” on human primary fibroblasts. Results show that “space ginseng yeast” can improve the cell morphology and survival rate in the human primary fibroblasts induced by microgravity; restore the expression and arrangement of cytoskeletal protein like Tubulin, and extracellular matrix protein like Integrin and Fibronectin; as well as inhibit the abnormal expression of MMP-1 protein. The protective effect of “space ginseng yeast”, which is diluted by 20 to 500 times, is better, and the protective effect of 100 times diluted “space ginseng yeast” shows the most obvious result.
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