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中文摘要: 建立了膏霜类化妆品中10种合成麝香的气相色谱-质谱联用(GC-MS)分析方法。样品加入氘代同位素内标后，用正己烷提取，提取液经基体分散固相萃取(MSPD)净化处理，以VF-WAXms毛细管色谱柱分离，选择特征离子监测扫描模式(SIM)测定，采用标准曲线法定量。结果表明，10种合成麝香的线性范围为0.01～0.2 mg/L，相关系数均大于0.99，定量限为0.05～0.10 mg/kg，加标回收率为80.1%～102.2%，相对标准偏差(RSD)均小于5%。
Abstract:An analytical method was established for simultaneous determination of ten kinds of synthetic musk in cream cosmetics using gas chromatography-mass spectrometry (GC-MS). Samples were spiked with deuterium-labeled isotope internal standards and extracted by n-hexane. Then the extract was purified with matrix solid-phase dispersion (MSPD) and separated by a VF-WAXms capillary column. All the compounds were detected with selected ion monitoring (SIM) scanning mode. Quantification was carried out using standard plot calibration. Results show that the ten kinds of synthetic musk display a good linear relationship within the mass concentration range of 0.01~0.2 mg/L and the correlation coefficients are all higher than 0.99. The quantification limits (LOQs) of the synthetic musk are in the range of 0.05～0.10 mg/kg. Values of spiked recoveries are found to be from 80.1% to 102.2% with all relative standard deviations (RSD) lower than 5%.
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|NING Xiao-jun||Food & Chemicals Quality Inspection Institute, Shanghai Institute of Quality Inspection and Technical Research, Shanghai 200233, China|