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日用化学工业:2017,Vol.>>Issue(5):272-276
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广藿香精油抗炎祛痘功效研究
王玥,郭苗苗,施雁勤,潘仙华,卢艳花,曹平
(上海应用技术大学,上海 201418)
nti-acne efficacy of essential oil from Pogostemon cablin (Blanco) Benth.
WANG Yue,GUO Miao-miao,SHI Yan-qin,PAN Xian-hua,LU Yan-hua,CAO Ping
(Shanghai Institute of Technology, Shanghai 201418, China)
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投稿时间:2016-12-15    
中文摘要: 采用气相色谱-质谱联用技术对广藿香精油成分进行分析。通过细胞毒性实验确定广藿香精油对人急性单核细胞(THP-1)的安全质量浓度。利用痤疮丙酸杆菌(P. acnes)刺激THP-1建立的特异性痤疮炎症细胞模型考察广藿香精油对炎症因子IL-1β的影响。通过荧光实时定量逆转录聚合酶链反应(qRT-PCR)初步探讨广藿香精油抗炎祛痘的作用机制。研究结果表明:广藿香精油在最大安全质量浓度12.5 mg/L时,对炎症细胞模型中P. acnes活性影响较小,对IL-1β的分泌具有明显的抑制作用(抑制率66.54%),可显著降低细胞内Toll样受体2(TLR2) mRNA的转录(抑制率73.73%),从而起到抑制炎症信号转导和继发性炎症介质生成的作用。
Abstract:Chemical composition of the essential oil from Pogostemon cablin (Blanco) Benth. (EOP) was quantitatively analyzed by gas chromatography-mass spectrometry (GC-MS). The safe mass concentration of the EOP to Human Acute Mononuclear Cells (THP-1) was determined via cytotoxicity screening test. An inflammatory acne model was established by stimulating THP-1 with Propionibacterium acnes (P. acnes). Subsequently, the effect of the EOP on the expression of proinflammatory cytokine IL-1β was assessed. The anti-acne mechanism of the EOP was examined by qRT-PCR. Results show that at maximum safe mass concentration of 12.5 mg/L of the EOP, the influence on the activity of P. acnes is rather small and the secretion of IL-1β is significantly inhibited by a rate of 66.54%. The EOP also significantly reduces the mRNA level of Toll-like receptor 2 (TLR2) by 73.73%. Thereby, the EOP inhibits proinflammatory signal transduction and production of secondary inflammatory mediators.
文章编号:     中图分类号:TQ658    文献标志码:
基金项目:教育和科研协同创新计划——上海市香料香精及化妆品协同创新中心项目资助(1021ZK162001) 教育和科研协同创新计划——上海市香料香精及化妆品协同创新中心项目资助(1021ZK162001)
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